How GlycoShield Works
Explore our computational pipeline for ensemble-based glycan shielding analysis
1. The Viral Glycan Shield
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The GlycoShield pipeline has been developed together by the Gnanakaran Group, the Berndsen Group, and the SimBioSys Lab.
GLACIER is a community-facing platform that provides computational tools and infrastructure for the analysis and modeling of glycans, glycoproteins, and other glycoconjugates. It integrates physics-based simulations, data-driven methods, and structural analyses for scalable research across glycoscience and immunology.
Upload Files & Configure
Upload your research files and configure analysis parameters
Each folder must contain: At least one .pdb file, at least one .ali file, glyc.dat, and input.dat
⚡ Each folder can have its own configuration (NRUNS, GEF Probe Radius, Attach Gaps)
Processing Time & Pipeline Stages
The complete GlycoShield analysis involves multiple computational stages. Times shown are for generating an ensemble of ~1000 frames:
⚡ For comparison: Typical time to generate equivalent ensembles using Molecular Dynamics (MD): several weeks with H100 NVIDIA GPU or equivalent.
A results link will be provided immediately upon submission where you can check the status and access your results once ready.
Related Publications
If you use GlycoShield in your research, please cite our related publications:
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Cite This Analysis
If you use GlycoShield analysis in your research, please cite GLACIER.
@software{glycoshield2025,
title = {{GlycoShield Analysis via GLACIER Platform}},
author = {{SimBioSys Lab}},
organization = {Northeastern University},
year = {2025},
url = {https://glacier-simbiosys.com/glycoshield},
note = {Ensemble-based geometric exposure analysis}
}For questions about citations or to report issues, please contact simbiosyslab.neu@gmail.com