Ensemble Modelling and
Quantification of
GLYCAN SHIELDING
on viral surface proteins.

Ensemble-based geometric exposure analysis for quantifying glycan shielding on viral surface proteins.

Predict
ANTIBODY INTERFACES
with AI precision.

Identify antibody-antigen binding sites with deep learning. MSA-powered neural networks analyze evolutionary patterns and 3D structure for epitope and paratope predictions.

MSA-based evolutionary analysis

Graph neural network predictions

Per-residue confidence scores

GLACIER is a community-facing platform that provides computational tools and infrastructure for the analysis and modeling of glycans, glycoproteins, and other glycoconjugates. It integrates physics-based simulations, data-driven methods, and structural analyses for scalable research across glycoscience and immunology.

Citation

Cite GLACIER

If you use GLACIER in your research, please cite our work to help others discover and build upon this platform.

@software{glacier2025,
  title = {{GLACIER: A comprehensive platform for ensemble-based geometric exposure analysis of glycosylated proteins}},
  author = {{SimBioSys Lab}},
  organization = {Northeastern University},
  year = {2025},
  url = {https://glacier-simbiosys.com},
  note = {Version 1.0}
}

For questions about citations or to report issues, please contact simbiosyslab.neu@gmail.com

Free & Open Access

No barriers to scientific discovery

This webserver is freely accessible to all users for academic, educational, and non-commercial research purposes. No login, subscription, or institutional affiliation is required to access the core functionality.

Users may submit jobs, visualize results, and download outputs without charge. The platform is provided to support the scientific community in advancing research on viral glycoproteins, antibody–antigen interactions, and immunogen design.

We encourage use by experimentalists, computational researchers, educators, and trainees.

Citation Request

Users are asked to acknowledge the use of this webserver in resulting publications by citing the relevant references provided on the site.

Fair Use Policy

The developers make no guarantee of uninterrupted service and reserve the right to introduce reasonable usage limits to ensure fair access for all users.

GLACIER